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Xanthi I Couroucli Selected Research

Cytochrome P-450 CYP1A2 (CYP1A2)

1/2018β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.
1/2017Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.
5/2015Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.
5/2015Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.
10/2011Omeprazole attenuates hyperoxic lung injury in mice via aryl hydrocarbon receptor activation and is associated with increased expression of cytochrome P4501A enzymes.
4/2011Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.
11/2010Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo.
8/2004Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.

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Xanthi I Couroucli Research Topics

Disease

21Lung Injury
04/2022 - 03/2002
19Hyperoxia
10/2018 - 03/2002
9Bronchopulmonary Dysplasia
04/2022 - 06/2006
8Inflammation (Inflammations)
10/2018 - 11/2011
4Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
10/2018 - 03/2002
3Acute Lung Injury
10/2018 - 03/2006
2Pneumonia (Pneumonitis)
03/2013 - 03/2002
1Retinopathy of Prematurity (Retrolental Fibroplasia)
02/2018
1Blindness (Hysterical Blindness)
02/2018
1Wounds and Injuries (Trauma)
01/2017
1Body Weight (Weight, Body)
09/2014
1Neoplasms (Cancer)
01/2011
1Carcinogenesis
11/2010
1Hepatocellular Carcinoma (Hepatoma)
03/2007
1Respiratory Insufficiency (Respiratory Failure)
03/2006

Drug/Important Bio-Agent (IBA)

17EnzymesIBA
10/2018 - 03/2002
15Cytochrome P-450 CYP1A1 (CYP1A1)IBA
04/2022 - 03/2002
15Oxygen (Dioxygen)IBA
04/2022 - 03/2002
11Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
10/2018 - 03/2006
8Messenger RNA (mRNA)IBA
04/2018 - 03/2002
8Cytochrome P-450 CYP1A2 (CYP1A2)IBA
01/2018 - 08/2004
8CytochromesIBA
05/2015 - 03/2002
5Proteins (Proteins, Gene)FDA Link
04/2018 - 12/2008
5Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
03/2013 - 03/2002
4Reactive Oxygen Species (Oxygen Radicals)IBA
10/2018 - 11/2011
4Corn Oil (Oil, Corn)IBA
01/2018 - 10/2011
3DNA AdductsIBA
10/2018 - 01/2011
3LipidsIBA
10/2018 - 10/2011
3LuciferasesIBA
04/2011 - 03/2007
2CytokinesIBA
10/2018 - 05/2015
2NF-kappa B (NF-kB)IBA
04/2018 - 01/2014
2quinone (benzoquinone)IBA
01/2017 - 03/2013
2NAD (NADH)IBA
01/2017 - 03/2013
2ApoproteinsIBA
05/2015 - 12/2008
2Interleukin-6 (Interleukin 6)IBA
05/2015 - 09/2014
2Omeprazole (Prilosec)FDA LinkGeneric
11/2011 - 10/2011
1QuercetinIBA
04/2018
1NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA
04/2018
1NADP (NADPH)IBA
04/2018
1Retinaldehyde (Retinal)IBA
02/2018
1Reactive Nitrogen SpeciesIBA
02/2018
1beta-NaphthoflavoneIBA
01/2018
1Oxidoreductases (Dehydrogenase)IBA
01/2017
1FlavonoidsIBA
01/2017
1Malondialdehyde (Propanedial)IBA
05/2015
1SmokeIBA
10/2014
1Benzo(a)pyreneIBA
10/2014
1F2-Isoprostanes (F2 Isoprostanes)IBA
09/2014
1Biomarkers (Surrogate Marker)IBA
01/2014
1Phosphotransferases (Kinase)IBA
01/2014
1SuspensionsIBA
10/2013
1microsomal glutathione S-transferase-IIBA
03/2013
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
11/2011
1CarcinogensIBA
01/2011
1Nitric Oxide (Nitrogen Monoxide)FDA Link
03/2006

Therapy/Procedure

1Therapeutics
03/2002